Title

CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity

Document Type

Article

Publication Date

2011

Abstract

A shared pathology among many neurological and neurodegenerative disorders is neuronal loss. Cannabinoids have been shown to be neuroprotective in multiple systems. However, both agonists and antagonists of the CB 1 cannabinoid receptor are neuroprotective, but the mechanisms responsible for these actions remain unclear. Recently a CB 1 receptor interacting protein, CRIP1a, was identified and found to alter CB 1 activity. Here we show that in an assay of glutamate neurotoxicity in primary neuronal cortical cultures CRIP1a disrupts agonist-induced neuroprotection and confers antagonist-induced neuroprotection. © 2011 Elsevier Ireland Ltd.

Publication Title

Neuroscience letters

Volume

503

Issue

3

First Page

224

Last Page

228

Comments

This article was published in Neuroscience letters, Volume 503, Issue 3, Pages 224-228.

The published version is available at http://dx.doi.org/10.1016/j.neulet.2011.08.041.

Copyright © 2011 Elsevier.

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