Title

A putative role for apelin in the etiology of obesity

Document Type

Article

Publication Date

2008

Abstract

Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity. © 2008 Elsevier Inc. All rights reserved.

Publication Title

Biochemical and biophysical research communications

Volume

368

Issue

3

First Page

815

Last Page

819

Comments

This article was published in Biochemical and biophysical research communications, Volume 368, Issue 3, Pages 815-819.

The published version is available at http://dx.doi.org/10.1016/j.bbrc.2008.02.008.

Copyright © 2008 Elsevier.

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