Title

Factorial design approach to evaluate interactions between electrically assisted enhancement and skin stripping for delivery of tacrine.

Document Type

Article

Publication Date

3-2-2005

Abstract

The objective of this work was to study the mechanisms of action of iontophoresis and electroporation and their interaction effects on delivery of tacrine hydrochloride in vitro across intact and stripped rat skin. Experiments were done according to a full factorial design, to quantify the effects of iontophoresis (X1), electroporation (X2) and stripped skin (X3) alone and in combination on cumulative drug delivery at 6 h. Mathematical model eliciting the main effects of the factors and their interaction on cumulative tacrine delivery in 6 h shows that all three techniques examined alone have a positive impact on the permeation of tacrine, the greatest enhancement in delivery achieved by iontophoresis. However, iontophoresis in combination with electroporation or skin stripping yielded no improvement in delivery compared to iontophoresis alone. The most significant enhancement is seen when all three methods of assisted delivery are done in combination. Iontophoresis appears to control drug delivery to the exclusion of other enhancement methods. Electroporation appears to cause formation of a large depot of tacrine in the skin.

Publication Title

Journal of controlled release : official journal of the Controlled Release Society

Volume

103

Issue

1

First Page

113

Last Page

121

PubMed ID

15710505

Comments

This article was published in Journal of Controlled Release, Volume 103, Issue 1, March 2005. The published version is available at doi:10.1016/j.jconrel.2004.11.026. Copyright © 2005 Elsevier.

This document is currently not available here.

COinS