Title

Treatment of depression in patients with epilepsy

Document Type

Article

Publication Date

2012

Abstract

Depression is more prevalent in patients with epilepsy than in the general population. The condition remains underdiagnosed because of underreporting of signs and symptoms. Another reason for lack of treatment is the belief that antidepressants have proconvulsant effects. Many antidepressants are known to lower the seizure threshold; however, data indicate that, at low doses, antidepressants possess anticonvulsant properties. Evidence also suggests that when an antidepressant is used within its therapeutic dosage range, the risk of seizure activity is low. When selecting an antidepressant for use in a patient with epilepsy, the clinician should carefully consider drug-drug interactions between antiepileptics and antidepressants. In general, selective serotonin reuptake inhibitors are considered first-line therapy. The efficacy of antidepressants in epilepsy patients may be enhanced with supportive therapy or psychotherapy.

Publication Title

U.S.Pharmacist

Volume

37

Issue

11

First Page

29

Last Page

32

Comments

This article was published in U.S.Pharmacist, Volume 37, Issue 11, Pages 29-32.

The published version is available at http://www.uspharmacist.com/content/c/37593/ .

Copyright © 2012 Jobson, LLC.

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