Genetic Polymorphisms of Metabolic Enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and Gastric Carcinoma Susceptibility

Authors

Ya-Ping Luo, Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan 410013, China
Hanchun Chen, Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, 410013, ChinaFollow
Md. Asaduzzaman Khan, Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, 410013, ChinaFollow
Fang-Zhi Chen, Department of Urology, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China
Xin-Xing Wan, Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, 410013, ChinaFollow
Bo Tan, Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, 410013, China
Fang-Dan Ou-Yang, Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, 410013, China
Dianzheng Zhang, Philadelphia College of Osteopathic MedicineFollow

Document Type

Article

Publication Date

2-1-2011

Abstract

Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. In this study, the relationships between genetic polymorphisms of phase I metabolic enzymes including cytochrome P450 1A1 (CYP1A1), CYP2D6 and phase II metabolic enzymes such as glutathione S-transferase M1 (GSTM1) and GSTT1 and gastric carcinoma susceptibility were investigated. Genomic DNA was isolated from the peripheral blood of 129 healthy controls and 123 gastric carcinoma patients from Han ethnic group of Hunan Province located in Central South China. The genetic polymorphisms of the above mentioned enzymes were analyzed using PCR-RFLP techniques. There was no significant difference among the frequencies of CYP1A1 and/or CYP2D6 gene's wild type, heterozygous or homozygous mutations between the gastric carcinoma group and control group. But the differences among the frequencies of GSTM1 and GSTT1 null genotype between the gastric carcinoma and control group were significant (both P < 0.05). Also there were significant differences in the frequencies of GSTM1 null in high/high-middle differentiated, middle differentiated, middle-low differentiated and low differentiated gastric tumor separately. GSTM1 null showed an increased risk in middle-low differentiated and low differentiated gastric carcinoma type, but GSTT1 null was not a risk factor for the four pathological types of gastric carcinoma mentioned above. We report here that the genotypes of CYP1A1 and CYP2D6 are not associated with gastric carcinoma risk; GSTM1 null, but not GSTT1 null inheritably increases risk of some pathological types of gastric carcinoma in Han ethnic population of Hunan Province.

Publication Title

Tumor Biology

Volume

32

Issue

1

First Page

215

Last Page

222

PubMed ID

20878561

Comments

This article was published in Tumor Biology, Volume 32, Issue 1, March 12, 2011, Pages 215-222.

The published version is available at http://dx.doi.org/10.1007/s13277-010-0115-8

Copyright ©2011 International Society of Oncology and BioMarkers (ISOBM)

Recommended Citation

Luo, Ya-Ping; Chen, Hanchun; Khan, Md. Asaduzzaman; Chen, Fang-Zhi; Wan, Xin-Xing; Tan, Bo; Ou-Yang, Fang-Dan; and Zhang, Dianzheng, "Genetic Polymorphisms of Metabolic Enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and Gastric Carcinoma Susceptibility" (2011). PCOM Scholarly Papers. 20.
https://digitalcommons.pcom.edu/scholarly_papers/20