Document Type

Article

Publication Date

2-25-2017

Abstract

Fibronectin is a matrix glycoprotein which has not only been found to be over-expressed in several cancers, but has been shown to participate in several steps of tumorigenesis. The purpose of this review is to illustrate how aberrant fibronectin expression influences tumor growth, invasion, metastasis and therapy resistance. In particular, this review will focus on the interactions between cell receptor ligands and fibronectin and how this interaction influences downstream signaling events that aid tumor progression. This review will further discuss the possible implications of therapeutic drugs directed against fibronectin and/or cellular interactions with fibronectin and will additionally discuss novel approaches by which to limit intra- and extra-tumoral fibronectin expression and the cellular events which lead to aberrant fibronectin expression. It is anticipated that these studies will set a basis for future research that will not only aid understanding of fibronectin and its prognostic significance, but will further elucidate novel targets for therapeutics.

Publication Title

Journal of Cancer

Volume

8

Issue

4

First Page

674

Last Page

682

PubMed ID

28367247

Comments

This article was published in Journal of Cancer, Volume 8, Issue 4, Pages 674-682.

The published version is available at http://dx.doi.org/10.7150/jca.16901.

Copyright © 2017. CC BY-NC.

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