Title

The Role of Stably Committed and Uncommitted Cells in Establishing Tissues of the Somite

Document Type

Article

Publication Date

4-15-1998

Abstract

Somites are blocks of embryonic mesoderm tissue that give rise to skeletal muscle, cartilage, and other connective tissues. The development of different tissues within the somite is influenced by adjacent structures, in particular, the neural tube and notochord. Results of experiments performed in vivo and in vitro suggest that somites contain populations of cells stably programmed to undergo either skeletal myogenesis or chondrogenesis and a population uncommitted to either pathway. The fate of the uncommitted cells would depend on a transfer of information from the committed cells. Communication between committed and uncommitted cells is regulated by cell and tissue interactions that either activate or inhibit this process.

Publication Title

Annals of the New York Academy of Sciences

Volume

842

First Page

16

Last Page

27

PubMed ID

9599289

Comments

This article was published in Annals of the New York Academy of Sciences, Volume 842, Pages 16-27.

The published version is available at http://dx.doi.org/10.1111/j.1749-6632.1998.tb09627.x .

Copyright © 1998.

This document is currently not available here.

COinS