MRSA Otorrhea: A Case Series and Review of the Literature

Document Type

Article

Publication Date

2-1-2011

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) has become an increasingly common cause of difficult-to-treat head and neck infections. We report a retrospective analysis of 3 cases of MRSA otorrhea treated in our clinic between 2007 and 2009. Culture analysis of otorrhea isolates revealed MRSA infections with identical drug sensitivities. Treatment success was achieved using combinations of linezolid with gentamicin ear drops for 3 to 4 weeks or trimethoprim/sulfamethoxazole (TMP/SMX) with gentamicin drops for 6 weeks. This study illustrates the importance of determining individual drug sensitivities for optimal treatment and maintaining current knowledge of the local MRSA strains. Empiric combination therapy of TMP/SMX with gentamicin is an effective first-line treatment for MRSA otorrhea. Regional differences in clindamycin sensitivities warrant clinical discretion. Fluoroquinolones should be avoided because of high rates of resistance unless culture sensitivity determines that they are appropriate. First-line agents for severe infections include combination therapy with vancomycin or linezolid.

Publication Title

Ear, Nose, & Throat Journal

Volume

90

Issue

2

First Page

60

Last Page

79

PubMed ID

21328227

Comments

This article was published in Ear, Nose, & Throat Journal, Volume 90, Issue 2, February 2011, Pages 60-79.

The published version is available at http://www.entjournal.com/article/mrsa-otorrhea-case-series-and-review-literature

Copyright © 2011 Vendome Group, LLC.

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