Title

Frank Stinchfield award: Titanium surface with biologic activity against infection

Document Type

Article

Publication Date

2004

Abstract

Despite immense improvements, periprosthetic infection continues to compromise the result of otherwise successful joint arthroplasty. There are various limitations in the treatment of periprosthetic infection, the most important of which is the inability to deliver antibiotics to the local tissue without the need for intravenous administration. We have developed a novel route to covalently tether vancomycin to a metal (titanium) surface, which showed effective bactericidal activity because of a vancomycin coupling. The chemistry of tethering does not affect the biological activity of the biofactors that are attached to the metal surface. This technology holds great promise for the manufacturing of "smart" implants that can be self protective against periprosthetic infection, or can be used for the treatment of periprosthetic infections when they occur.

Publication Title

Clinical orthopaedics and related research

Issue

429

First Page

33

Last Page

38

Comments

This article was published in Clinical orthopaedics and related research, Issue 429, Pages 33-38.

The published version is available at http://dx.doi.org/10.1097/01.blo.0000150116.65231.45.

Copyright © 2004.

This document is currently not available here.

COinS