Title

Are Analogue Insulins Superior to Human Insulin in Clinical Practice?

Document Type

Article

Publication Date

6-1-2010

Abstract

Insulin analogues were designed to provide more physiologic pharmacokinetic and pharmacodynamic properties compared with human insulin. This article examines the literature over a 2-year period, focusing on studies directly comparing analogue and human insulin in controlled clinical trials and large observational studies documenting the introduction of, or change to, analogue insulin in clinical practice. Findings indicate that analogues provide objective benefits that include improved glycemic control, lower risk of hypoglycemia, lower glucose variability, and (for insulin detemir) reduced weight gain. Recent data with analogues also explore their safety and efficacy in special patient groups such as children and adolescents. These data complement increasing evidence that analogues offer improved acceptability and accessibility to people with diabetes.

Publication Title

Current Diabetes Reports

Volume

10

Issue

3

First Page

176

Last Page

183

PubMed ID

20425580

Comments

This article was published in Current Diabetes Reports, Volume 10, Issue 3, June 2010, Pages 176-83.

The published version is available at http://dx.doi.org/10.1007/s11892-010-0104-8

Copyright © 2010 Springer, Part of Springer Science+Business Media

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