Title

Thiazolidinediones and Congestive Heart Failure: A Judicious Balance of Risks and Benefits

Document Type

Article

Publication Date

5-1-2009

Abstract

Thiazolidinediones are oral antihyperglycemic drugs that have gained significant popularity for use in the treatment of type 2 diabetes mellitus. Their insulin sensitizing effects lead to better glycemic control, in addition to improvements in several cardiovascular parameters independent of blood glucose levels. The pleiotropic effects of thiazolidinediones have led to several cardiovascular outcome studies, many of which have shown promising data, but some of which bring about significant concern. Additionally, the propensity to cause weight gain, fluid retention, peripheral edema, and increased risk of heart failure hospitalizations continue to pose significant challenges for clinicians using these agents in patients with congestive heart failure.

Publication Title

Cardiology in Review

Volume

17

Issue

3

First Page

132

Last Page

135

PubMed ID

19384087

Comments

This article was published in Cardiology in Review, Volume 17, Issue 3, May-June 2009, Pages 132-5.

The published version is available at http://dx.doi.org/10.1097/CRD.0b013e31819faab2

Copyright © 2009 Lippincott Williams & Wilkins, Inc.

This document is currently not available here.

COinS