Title

Induction of mitogen-inducible nuclear orphan receptor by interleukin 1 in human synovial and gingival fibroblasts

Document Type

Article

Publication Date

1998

Abstract

High levels of interleukin 1 (IL-1) found in inflammatory diseases such as rheumatoid arthritis and periodontitis act on the local fibroblasts, resulting in an altered phenotype characterized by hyperplasia and the production of inflammatory mediators and destructive enzymes. The goal of this study was to identify genes induced as an early response to IL-1 in synovial and gingival fibroblasts which might play a regulatory role in the cascade of events leading to their activation. Using the technique of mRNA differential display, we have identified the mitogen-inducible nuclear orphan receptor (MINOR) as a gene up-regulated by IL-1 in human synovial and gingival fibroblasts. The rapid induction of both mRNA and DNA binding activity suggests that MINOR may play an important early role in regulating the response of fibroblasts to inflammation.

Publication Title

Biochemical and biophysical research communications

Volume

251

Issue

1

First Page

334

Last Page

338

Comments

This article was published in Biochemical and biophysical research communications, Volume 251, Issue 1, Pages 334-338.

The published version is available at http://dx.doi.org/10.1006/bbrc.1998.9477.

Copyright © 1998 Elsevier.

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