5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions
The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5-HT3R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N-benzyl group, resulted in the discovery of a partial agonist.
Bioorganic and Medicinal Chemistry Letters
Parihar, Harish S.; Suryanarayanan, Asha; Ma, Chun; Joshi, Prasad; Venkataraman, Padma; Schulte, Marvin K.; and Kirschbaum, Karen S., "5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions" (2001). PCOM Scholarly Papers. 1139.
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