Title

Modeling oxygen effects in tissue-preparation neuronal-current MRI

Document Type

Article

Publication Date

2007

Abstract

Tissue-preparation neuronal-current MRI (ncMRI) was recently developed to directly detect neuronal activity without hemodynamic contamination. However, as a paramagnetic substance, the oxygen molecules present in the tissue may also alter the ncMRI signal through relaxivity and susceptibility effects. To study the effects of oxygen on the ncMRI signal and estimate their impact on tissue-preparation experiments, oxygen-induced MRI signal changes were formulated as a function of oxygen concentration (OC) of gas, oxygen consumption rate, and imaging parameters. Under favorable conditions of these parameters, the maximum oxygen-induced signal magnitude and phase change were estimated to be 0.32% and 3.85°, respectively. Considering that the ncMRI signal changes obtained in previous tissue-preparation experiments (3-5% in magnitude, 0.8-1.7° in phase) were tens or hundreds of times larger than the corresponding oxygen-induced signal changes (0.03% in magnitude, 0.03-0.07° in phase), it is concluded that the oxygen had negligible effects in the previous experiments.

Publication Title

Magnetic Resonance in Medicine

Volume

58

Issue

2

First Page

407

Last Page

412

Comments

This article was published in Magnetic Resonance in Medicine, Volume 58, Issue 2, Pages 407-412.

The published version is available at http://dx.doi.org/10.1002/mrm.21259.

Copyright © 2007 Wiley.

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