The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2017

Portomesenteric Vein Thrombosis After Laparoscopic Sleeve Gastrectomy for Morbid Obesity., Leslie S Anewenah, Mohammed Asif, Richard Francesco, and Prashanth Ramachandra

Proof of Concept Studies of Chlamydia Pneumoniae Infection as a Trigger for Late-onset Alzheimer Disease, Brian J. Balin PhD

Chlamydia Pneumoniae as an Etiologic Agent for Late-Onset Alzheimer's Disease, Brian J. Balin PhD, Christine Hammond, Christopher S. Little, Susan Hingley, Denah Appelt, Judith A. Whittum-Hudson, Herve C. Gerard, and Alan P. Hudson

Osteopathic Approach to Treating a Patient with Congenital Infantile Torticollis Reveals Unusual Presentation of Absence of Concomitant Cranial Base Strain Pattern: A Case Report, Murray R. Berkowitz


Role of Myo/Nog Cells in Neuroprotection: Evidence from the Light Damaged Retina., Alice Brandli, Jacquelyn Gerhart, Christopher K Sutera, Sivaraman Purushothuman, Mindy George-Weinstein, Jonathan Stone, and Arturo Bravo-Nuevo


A New Genus and Species of Marine Catfishes (Siluriformes; Ariidae) From the Upper Eocene Birket Qarun Formation, Wadi El-Hitan, Egypt, Sanaa E El-Sayed, Mahmoud A Kora, Hesham M Sallam, Kerin M. Claeson, Erik R Seiffert, and Mohammed S Antar


Development of Diagnostic SCAR Markers for Genomic DNA Amplifications in Breast Carcinoma by DNA Cloning of High-GC RAMP-PCR Fragments, Shangyi Fu, Jingliang Cheng, Chunli Wei, Luquan Yang, Xiuli Xiao, Dianzheng Zhang, M David Stewart, and Junjiang Fu

Antibody Conjugated, DNA-Based Nanocarriers Intercalated with Doxorubicin Eliminate Myofibroblasts in Explants of Human Lens Tissue., Jacquelyn Gerhart, Marvin Greenbaum, Lou Casta, Anthony Clemente, Keith Mathers, Robert Getts, and Mindy George-Weinstein


Cyclosporine a Alters Expression of Renal Micrornas: New Insights into Calcineurin Inhibitor Nephrotoxicity, Jennifer L Gooch, Clayton King, Cynthia E Francis, Paul S Garcia, and Yun Bai

Cellular modeling of inflammation relevant to Alzheimer's disease: Molecular and cytokine analysis of host responses following chlamydial infection of human thp-1 monocytes, Christine Hammond, Jonathan M. Anzmann, Abhi P. Jain, Susan T. Hingley, and Brian J. Balin PhD

Treatment Options in Managing Acute Perioperative Pain, Samuel N. John, Melissa Williams, and Christina Hunley

Blended Learning Educational Format for Third-Year Pediatrics Clinical Rotation., Erik E. Langenau, Robert Lee, and Marci Z. Fults


Different RET Gene Mutation-Induced Multiple Endocrine Neoplasia Type 2A in 3 Chinese Families, Qiuli Liu, Dali Tong, Wenqiang Yuan, Gaolei Liu, Gang Yuan, Weihua Lan, Dianzheng Zhang, Jun Zhang, Zaoming Huang, Yao Zhang, and Jun Jiang

A Somatic HIF2α Mutation-Induced Multiple and Recurrent Pheochromocytoma/Paraganglioma with Polycythemia: Clinical Study with Literature Review., Qiuli Liu, Yan Wang, Dali Tong, Gaolei Liu, Wenqiang Yuan, Jun Zhang, Jin Ye, Yao Zhang, Gang Yuan, Qingxing Feng, Dianzheng Zhang, and Jun Jiang

The Role of Micronutrients in the Response to Ambient Air Pollutants: Potential Mechanisms and Suggestions for Research Design, Colette N Miller and Srujana Rayalam

Sociodemographic Determinants of Out-of-Pocket Expenditures for Patients Using Prescription Drugs for Rheumatoid Arthritis, Kumar Mukherjee and Khalid M. Kamal


Trends in Hospital Admissions Due to Antidepressant-Related Adverse Drug Events from 2001 to 2011 in the U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, and Jianwei Xuan

Evolution of the Hominoid Scapula and Its Implications for Earliest Hominid Locomotion, Michael S. Selby and C Owen Lovejoy

Hominoid Scapular Morphology Suggests a Generalized Last Common Ancestor, Michael S. Selby and C. Owen Lovejoy


Loss of Caveolin-1 Alters Extracellular Matrix Protein Expression and Ductal Architecture in Murine Mammary Glands., Christopher Thompson, Sahar Rahim, Jeremiah Arnold, and Abigail Hielscher


Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting, Jennifer Peyling Wang and Abigail Hielscher

An Overview of the Management of Concussion, Todd J. Woodard and Shari N. Allen

ISG15 Inhibits Cancer Cell Growth and Promotes Apoptosis, Mei-Juan Zhou, Fang-Zhi Chen, Han-Chun Chen, Xin-Xing Wan, Xi Zhou, Qian Fang, and Dianzheng Zhang

Submissions from 2016

Chlamydia Pneumoniae-Infected Astrocytes Alter Their Expression of ADAM10, BACE1, and Presenilin-1 Proteases, Zein Al-Atrache, Ahmad Cader, and Denah Appelt


Phytochemicals as Novel Agents for the Induction of Browning in White Adipose Tissue, Yusra Azhar, Ashish Parmar, Colette N Miller, Janaiya S Samuels, and Srujana Rayalam

Multifaceted Effects of Guggulsterone as Anti-obesity Agent, Yusra Azhar, Ashish Parmar, and Srujana Rayalam

Osteopathic Approach to Treating a Patient with New Onset Low Back Pain Following Injury Reveals Unusual Presentation of Bilateral and Symmetric Symptoms: A Case Report, Murray R. Berkowitz

Impact of Animated Spokes-Characters in Print Direct-to-Consumer Prescription Drug Advertising: An Elaboration Likelihood Model Approach., Nilesh S Bhutada, Brent L. Rollins, and Matthew Perri

Zinc-Binding Protein-89 (ZBP-89) Cooperates with NF-kB to Regulate Expression of Matrix Metalloproteinases (MMPs) in Response to Inflammatory Cytokines, Ruth C. Borghaei, Grzegorz Gorski, Sara Seutter, Janny Chun, Nelly Khaselov, and Stephanie Scianni

Neuroprotective effect of Myo/Nog cells in the stressed retina, A. Bravo-Nuevo, A. A. Brandli, Jacquelyn Gerhart, J. Nichols, M. Pitts, C. Sutera, S. Assali, V. Scheinfeld, Mindy George-Weinstein, and et al.


Apocynin Exerts Dose-Dependent Cardioprotective Effects by Attenuating Reactive Oxygen Species in Ischemia/Reperfusion, Qian Chen, Woodworth C. Parker, Issachar Devine, Regina Ondraskik, Tsion Habtamu, Kyle Bartol, Brendan Casey, Harsh Patel, William Chau, and Tarah Kuhn

The Sabertooth Salmon, Oncorhynchus rastrosus, gets a facelift., Kerin M. Claeson, E. B. Davis, B. L. Sidlauskas, and Z. M. Prescott

Distal triceps rupture associated with septic olecranon bursitis, Mark Denzine and Jack E. Kazanjian

Reciprocal Androgen Receptor/Interleukin-6 Crosstalk Drives Oesophageal Carcinoma Progression and Contributes to Patient Prognosis, Hongmei Dong, Jinjin Xu, Weiwei Li, Jinfeng Gan, Wan Lin, Jierong Ke, Jiali Jiang, Liang Du, Yuping Chen, Xueyun Zhong, Dianzheng Zhang, Sai-Ching Jim Yeung, Xiaotao Li, and Hao Zhang


Pelvic and Breast Examination Skills Curricula in United States Medical Schools: A Survey of Obstetrics and Gynecology Clerkship Directors, Lorraine Dugoff, Archana Pradhan, Petra Casey, John L Dalrymple, Jodi F Abbott, Samantha D Buery-Joyner, Alice Chuang, Amie J Cullimore, David A Forstein, Brittany S Hampton, Joseph M. Kaczmarczyk, Nadine T Katz, Francis S Nuthalapaty, Sarah M Page-Ramsey, Abigail Wolf, and Nancy A Hueppchen


A Systematic Review on the Use of Psychosocial Interventions in Conjunction with Medications for the Treatment of Opioid Addiction, K Dugosh, A. Abraham, B. Seymour, K. McLoyd, M. Chalk, and David Festinger

Recurrent Varicella in an Immunocompetent Woman, Joseph Dyer and Melinda Greenfield

Verbal communication impacts quality of life in patients with amyotrophic lateral sclerosis, Stephanie Felgoise, Vincenzo Zaccheo, Jason Duff, and Zachary Simmons

Use of the Internet to Obtain Drugs Without a Prescription Among Treatment-Involved Adolescents and Young Adults, David Festinger, K. Dugosh, N. Clements, A. Flynn, M. Falco, A. McLellan, and A. Arria

Examining the efficacy of a computer facilitated HIV prevention tool in drug court, David Festinger, K. Dugosh, A. Kurth, and D. Metzger


Synchrotron-based Nickel Mössbauer Spectroscopy., Leland B Gee, Chun-Yi Lin, Francis E. Jenney, Michael W W Adams, Yoshitaka Yoda, Ryo Masuda, Makina Saito, Yasuhiro Kobayashi, Kenji Tamasaku, Michael Lerche, Makoto Seto, Charles G Riordan, Ann Ploskonka, Philip P Power, Stephen P Cramer, and Lars Lauterbach


Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis, Abigail Hielscher, Kim Ellis, Connie Qiu, Josh Porterfield, and Sharon Gerecht

Fluorinated Caffeic Acid Phenethyl Ester: a Novel Anti-osteogenic molecule to Attenuate Excessive Bone Damage during Autoimmune Arthritis, Lauren Holland, Ramanjaneya V.R. Mula, Deepa Machiah, Xinyu Wang, and Rangaiah Shashidharamurthy


Microbes and Alzheimer's Disease, Ruth Itzhaki, Richard Lathe, Brian J. Balin, Melvyn J. Ball, Elaine L. Bearer, Heiko Braak, Maria J. Bullido, Chris Carter, Mario Clerici, and et al.


Effects of Anchor Structure and Glycosylation of Fcγ Receptor III on Ligand Binding Affinity, Ning Jiang, Wei Chen, Prithiviraj Jothikumar, Jaina M. Patel, Rangaiah Shashidharamurthy, Periasamy Selvaraj, and Cheng Zhu

Determination of Regional Flow Utilizing Microspheres in ex vivo Myocardial Ischemia/Reperfusion (MI/R) Injury, Tarah Kuhn, Sabrina Clark, Daniel Kuo, Stephanie Liu, Qian Chen, Robert Barsotti, and Lindon Young


Science AMA Series: Antarctic Peninsula Paleontology Project, Matt Lamanna, Julia Clarke, Pat O'Connor, Ross MacPhee, Erik Gorscak, Abby West, Chris Torres, Kerin M. Claeson, Meng Jin, Steve Salisbury, Eric Roberts, and Zubair Jinnah

Characterization of the [3Fe-4S](0/1+) cluster from the D14C variant of Pyrococcus furiosus ferredoxin via combined NRVS and DFT analyses., Lars Lauterbach, Leland B Gee, Vladimir Pelmenschikov, Francis Jenney, Saeed Kamali, Yoshitaka Yoda, Michael W W Adams, and Stephen P Cramer

Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity, Jocelyn Lippman-Bell

Exploring the role of synaptic layering, Jocelyn Lippman-Bell

Staging and Management of Heart Failure, Dusty Lisi and Valerie Tapia


Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis, Q. Liu, W. Yuan, D. Tong, G. Liu, W. Lan, Diangzheng Zhang, H. Xiao, Y. Zhang, J. Yang, and J. Zhang


Cerebellar nuclei neurons show only small excitatory responses to optogenetic olivary stimulation in transgenic mice: in vivo and in vitro studies, Huo Lu, Bo Yang, and Dieter Jaeger

New Horizons: Basal Insulin, Miriam Lulusa, Stephen Lee, Sara Reece, and Jennifer Elliott

Effects of NOX-1 on Real-Time Blood Nitric Oxide and Hydrogen Peroxide in Acute Hyperglycemia, Ashley Mawhinney, Michael Bertolet, Michael Minni, Robert Barsotti, Lindon Young, and Qian Chen

Error Analysis: Past, Present, and Future, George McCloskey

Compatibility of Norepinephrine Bitartrate with Levofloxacin and Moxifloxacin During Simulated Y-site Administration, Vicky Mody, Samit Shah, Jaymin Patel, and Michael C. Thomas


Immune Complex-Induced, Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes Is Prevented with Decoy FcyReceptors, Ramanjaneya V. R. Mula, Deepa Machiah, Lauren Holland, Xinyu Wang, Harish Parihar, Avadhesh Sharma, Periasamy Selvaraj, and Rangaiah Shashidharamurthy

Resveratrol Increases Catecholamine Synthesis in Macrophages: Implications on Obesity, Ashish Parmar, Ramanjaneya V. R. Mula, Yusra Azhar, Rangaiah Shashidharamurthy, and Srujana Rayalam

Treatment Sequencing for Childhood ADHD: A Multiple-Randomization Study of Adaptive Medication and Behavioral Interventions, William E. Pelham, Gregory A. Fabiano, James G. Waxmonsky, Andrew R. Greiner, Elizabeth M. Gnagy, Stefany Coxe, Jessica Verley, Ira Bhatia, Katy Tresco, and et al.

Still the Great Debate - "Fair Balance" in Direct-to-Consumer Prescription Drug Advertising; Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters", Brent L. Rollins

Who should receive extended infusion beta-lactam therapy?, Christopher Roman, Tia Solh, and Kendra M. Damer

MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway, Wei Sand, Ying Wang, Cong Zhang, Dianzheng Zhang, Cai Sun, Mingshan Niu, Zhe Zhang, Xiangyu Wei, Bin Pan, and et al.

MicroRNA-150 negatively regulates the function of CD4+ T cells through AKT3/Bim signaling pathway, Wei Sang, Cai Sun, Cong Zhang, Dianzheng Zhang, Ying Wang, Linyan Xu, and et al.

Olecranon and trochlear notch orientation is related to extended limb postures during locomotion, Michael Selby and C. O. Lovejoy

Is Olecranon Length Reflective of Adaptations for Speed or Power in Anthropoids?, Michael S. Selby

The functional anatomy of the carpo-metacarpal complex in anthropoids and its implications for the evolution of the hominoid hand, Michael S. Selby, Scott W. Simpson, and Owen C. Lovejoy

Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis, Vishal Singh, Beng Yeoh, Benoit Chassaing, Benyue Zhang, Piu Saha, Xia Xiao, Deepika Awasthi, Rangaiah Shashidharamurthy, Madhu Dikshit, and et al.

Alestid (Characiformes: Alestidae) fishes from the late Oligocene Nsungwe Formation, Rukwas Rift Basin, of Tanzania, W. Stevens, Kerin Claeson, and N. Stevens

Assessment of the Relationship between Self-Reported Cognitive Distortions and Adult ADHD, Anxiety, Depression, and Hopelessness, Craig Strohmeier, Brad Rosenfield, Robert A. DiTomasso, and J. Russell Ramsay


Management of hypercalcemia of malignancy, Sonia Thomas and Soo-Hwan Chung

Metformin Inhibits Castration-Induced EMT in Prostate Cancer by Repressing COX2/PGE2/STAT3 Axis, Dali Tong, Qiuli Liu, Gaolei Liu, Jing Xu, Weihua Lan, Yao Jiang, Hualiang Xiao, Dianzheng Zhang, and Jun Jiang


The HIF/PHF8/AR axis promotes prostate cancer progression., D Tong, Q Liu, G Liu, W Yuan, L Wang, Y Guo, W Lan, Dianzheng Zhang, S Dong, Y Wang, H Xiao, J Mu, C Mao, J Wong, and J Jiang


Brief compression-only cardiopulmonary resuscitation training video and simulation with homemade mannequin improves CPR skills., Gregory K Wanner, Arayel Osborne, and Charlotte H. Greene PhD

Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice, Hau Wu, Eric V. Brown, Nimish K. Acharya, Denah M. Appelt, Alexander Marks, Robert G. Nagele, and Venkat Venkataraman

Detecting Subnetwork-Level Dynamic Correlations, Yan Yan, Shangzhao Qiu, Zhuxuan Jin, Sihong Gong, Yun Bai, Jianwei Lu, and Tianwei Yu

The Role of NADPH Oxidase Isoform 1 (NOX1) in L-NAME-Induced Leukocyte-Endothelial Interactions in Rat Mesenteric Postcapillary Venules, Alita Zabrecky, Hung Pham, Amber Koon, Brian Reuter, Robert Barsotti, Lindon Young, and Qian Chen


Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein., Dianzheng Zhang, Boxv Zhou, Li Zhu, Md Asaduzzaman Khan, Tao He, Sufang Zhou, Jian He, Xiaoling Lu, Hanchun Chen, Yongxiang Zhao, and Junjiang Fu

Submissions from 2015

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase Blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline, Nimish K. Acharya, Eric L. Goldwaser, Martin M. Forsberg, George A. Godsey, Cristina A. Johnson, Abhirup Sarkar, Cassandra DeMarshall, Mary C. Kosciuk, Denah M. Appelt, and et al.

Vascular Mechanics in Decellularized Aortas and Coronary Resistance Microvessels in Type 2 Diabetic db/db Mice, Mircea Anghelescu, J. Tonniges, E. Calomeni, P. E. Shamhart, G. Agarwal, K. J. Gooch, and A. J. Trask

Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation, Charles E. Argoff, Michael J. Brennan, Michael Camilleri, Andrew Davies, Jeffrey Fudin, Katherine Galluzzi, Anthony Lembo, Steven P. Stanos, and R. Webster


Alzheimer's Risk Factors, Brian J. Balin, Christopher S. Little, and Denah Appelt

Comparison of the Effects of Myristoylated and Transactivating Peptide (TAT) Conjugated Mitochondrial Fission Peptide Inhibitor (P110) in Myocardial Ischemia/Reperfusion (I/R) Injury, Israel Benjamin, Jonathan Vu, Christina Lipscombe, Devon Stutzman, Carly Schmigdall, Harsh Patel, Qian Chen, Cathy J. Hatcher, Robert Barsotti, and Lindon H. Young

Identification Of Novel Polyglutamine-Expanded Aggregation Species In Spinal And Bulbar Muscular Atrophy., Tamar R Berger, Heather L. Montie, Pranav Jain, Justin Legleiter, and Diane Merry

Resolution of Hypothyroidism after Correction of Somatovisceral Reflex Dysfunction by Refusion of the Cervical Spine., Murray R. Berkowitz

Consumers' reactions to U.S. Food and drug administration-approved claims in print direct-to-consumer advertising, Nilesh Bhutada, J. Huh, Brent Rollins, and M. Perri

Factors predicting consumers' drug inquiry intention after exposure to a prescription drug advertisement: An exploratory analysis, Nilesh Bhutada, Brent Rollins, and M. Perri

Impact of endorser testimonials in direct-to-consumer advertising, Nilesh Bhutada, Brent Rollins, and M. Perri

Disease-specific direct-to-consumer advertising for reminding consumers to take medications, Nilesh S. Bhutada and Brent L. Rollins

Disease-specific direct-to-consumer advertising of pharmaceuticals: An examination of endorser type and gender effects on consumers' attitudes and behaviors, Nilesh S. Bhutada and Brent L. Rollins

A randomized, double-blind, solifenacin succinate versus placebo control, phase 4, multicenter study evaluating urinary continence after robotic assisted radical prostatectomy, F. J. Bianco, D. Albala, Laurence Belkoff, B. J. Miles, J. O. Peabody, W. He, J. S. Bradt, G. P. Haas, and T. E. Ahlering

Sleep-Related Problems and the Effects of Anxiety Treatment in Children and Adolescents., Nicole E Caporino, Kendra L Read, Nina Shiffrin, Cara Settipani, Philip C Kendall, Scott N Compton, Joel Sherrill, John Piacentini, John Walkup, Golda Ginsburg, Courtney Keeton, Boris Birmaher, Dara Sakolsky, Elizabeth Gosch, and Anne M Albano


Disrupting SUMOylation Enhances Transcriptional Function and Ameliorates Polyglutamine Androgen Receptor-Mediated Disease, Jason P. Chua, Satya L. Reddy, Zhigang Yu, Elisa Georgetti, Heather L. Montie, Sarmistha Mukherjee, Jake Higgins, Richard C. McEachin, Diane M. Robins, and Diane E. Merry

New fossil scombrid (Pelagia: Scombridae) fishes preserved as predator and prey from the Eocene of Senegal, Kerin M. Claeson, Raphael Sarr, Robert V. Hill, El Hadji Sow, Raymond Malou, and Maureen O'Leary

Sodium glucose co-transporter inhibitors for the management of diabetes mellitus: an opinion paper from the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy, Jennifer N. Clements, Heather P. Whitley, Jennifer J. D'Souza, Benjamin Gross, Rick Hess, Sara Wilson Reece, Chad Gentry, and Kayce Shealy

A Telemedicine-Based Intervention Reduces the Frequency and Severity of COPD Exacerbation Symptoms: A Randomized, Controlled Trial, Francis C. Cordova, David Ciccolella, Carla Grabianowski, John Gaughan, Kathleen Brennan, Frederick J. Goldstein, Michael R. Jacobs, and Gerard J. Criner


Invasive Breast Cancer Incidence in 2,305,427 Screened Asymptomatic Women: Estimated Long Term Outcomes during Menopause Using a Systematic Review., Winnifred Cutler, Regula Bürki, James Kolter, Catherine Chambliss, Erika Friedmann, and Kari Hart

Tetracycline tethered to titanium inhibits colonization by Gram-negative bacteria, H. Davidson, M. Poon, R. Saunders, I. M. Shapiro, N. J. Hickok, and Christopher S. Adams


Learners of a New Generation, Camille DiLullo

Symptomatic comorbidity, Robert A. DiTomasso and Bradley M. Rosenfield