Date of Award

2023

Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant

Department

Physician Assistant Studies

Abstract

Objective: The objective of this systematic review is to determine, “Does dapoxetine increase duration of sexual intercourse in men with premature ejaculation when compared with oral SSRIs?”

Study Design: A systemic review of two RCTs and one non RCT published between 2014 and 2020.

Data Sources: All three articles were researched using PubMed. The articles were published in peer reviewed journals and selected based on their validity and relevance to the clinical question, as well as including pertinent patient-oriented outcomes.

Outcome Measured: All three studies measured intravaginal ejaculatory latency time (IELT) using the stopwatch method (timing of intravaginal penetration to the time of ejaculation).

Results: In the non RCT by Simsek et al., there was an increase in IELT compared to the control (p = .001) demonstrated by a 0.9s mean change from baseline. In the RCT by Sahan et al., there was a decrease in IELT compared to the control (p > .05) demonstrated by a 4s mean change from baseline. In the RCT by Abu El-Hamd et al., there was a a decrease in IELT compared to the control (p < .001) demonstrated by a 2.23s mean change from baseline.

Conclusion: All three studies used in this systematic review prove that dapoxetine increases duration of sexual intercourse in males with PE, however two studies show that other oral SSRIs are more efficacious. This suggests that while dapoxetine may not be more effective than other SSRIs, it still may be an alternate treatment due to its similar IELT. Further research should include larger sample sizes, longer follow-up periods, increasing diversity of the patient population, include blinding, and utilize randomization and concealment when determining treatment groups.

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