Title
Is Juvederm Ultra Plus Effective For Treatment of Nasolabial Fold Wrinkles Over A One Year Period?
Date of Award
2016
Degree Type
Selective Evidence-Based Medicine Review
Degree Name
Master of Science in Health Sciences - Physician Assistant
Department
Physician Assistant Studies
Department Chair
John Cavenagh, MBA, PhD, PA-C
Abstract
Objective: The objective of this evidence based medicine review is to determine whether or not Juvederm Ultra Plus is effective in treating nasolabial fold wrinkles over a one year period.
Study Design: Three blinded, randomized controlled trials were reviewed and selected based on their relevance to the clinical question and their inclusion of patient oriented outcomes (POEMS).
Data Sources: Each study was obtained by searching Cochrane, PubMed databases, and product package insert.
Outcome Measured: The outcomes measured were improvement in NLF wrinkle on a five point Wrinkle Assessment Scale compared to baseline.
Results: The studies by Lupo et al, Goodman et al, and Allergan found a statistically significant reduction in nasolabial fold wrinkles compared to baseline over a one year period after injection with Juvederm Ultra Plus.
Conclusions: The results showed Juvederm Ultra Plus is an effective treatment for nasolabial folds over a one year period, as evidenced by at least a one point reduction in severity of nasolabial fold wrinkles as well as low numbers needed to treat (NNT) for all three studies.
Recommended Citation
Maloney, Meghan M., "Is Juvederm Ultra Plus Effective For Treatment of Nasolabial Fold Wrinkles Over A One Year Period?" (2016). PCOM Physician Assistant Studies Student Scholarship. 297.
https://digitalcommons.pcom.edu/pa_systematic_reviews/297